Abstract: [Abstract] Objective: To explore the clinical effect of radical resection of rectal carcinoma plus chemotherapy for improving the prognosis of patients with colorectal cancer. Methods: The clinical data of 90 patients with colorectal cancer were selected and divided into control group and research group (n=45) in accordance with the random number table. The cases in control group were taken radical resection of rectal carcinoma and the cases in research group were taken chemotherapy on the basis of control group. The adverse reactions, serum CA199 level, CEA level, quality of life and living condition were compared. Results: there was no significant difference of adverse reactions during treatment (P>0.05). Before treatment, there was no significant difference of serum CA199 level and CEA level between the two groups (P>0.05). After treatment, the serum CA199 level and CEA level between the two groups were decreased significantly and the decreased degree in research group was much greater than control group (P<0.05). The life quality score in research was significantly higher than the control group (P<0.05). All the patients were followed up to Jan.2017. The postoperative survival rate and postoperative survive period was significantly better than the control group (P<0.05). Conclusion: Radical resection of rectal carcinoma plus chemotherapy can improve the prognosis, the life quality of patients with colorectal cancer with no obvious adverse effect. It deserves to be spread and studied in the clinic.

Key words: Keywords: radical resection of rectal carcinoma, chemotherapy, rectal cancer, quality of life, adverse reactions