Abstract: Objective To summarize the nursing key points for patients with chronic subclavian artery occlusion receiving combined approach and guidewire intersection technology through perioperative nursing observation of 22 patients. Methods Patients with chronic subclavian artery occlusion （n=22） were treated with anterograde femoral artery approach and retrograde brachial artery approach. The occluded vessels were opened by guidewire intersection technology. All patients received comprehensive and careful nursing during the perioperative period, including preoperative examination and nursing preparation, psychological nursing and health education, intraoperative nursing cooperation, postoperative complication care and observation. Results All patients were successfully treated with scientific, systematic, and meticulous nursing. Twenty occluded cases were successfully opened, and the success rate was 90.9%. No serious complications occurred. Among the 20 patients followed up, there was no restenosis in 3 months （0%） and 2 cases in 1 year（0%）. Conclusion The application of combined approach and guidewire intersection technology in the treatment of chronic subclavian artery occlusion has a high success rate, and is a safe and effective treatment. Perioperative psychological nursing, monitoring of vital signs,prevention and nursing of complications are a powerful guarantee for a successful operation.

Key words: Combined approach, Guidewire intersection technology, Chronic occlusion of subclavian artery, Nursing experience