Abstract: Objective To investigate the clinical and pathological features of lymphoepithelioma-like carcinoma of the skin （LECS） and improve clinical diagnosis and treatment of the disease. Methods The clinical manifestations, gross pathological morphology, histological features, and immunohistochemical phenotype of a patient with LECS were analyzed, and the related literature was reviewed. Results The patient was an elderly male with a 1.3 cm dark red hard nodular lesion on the left cheek. The nodule was solid and without obvious capsule. Immunohistochemical results showed that the tumor cells were stained positive for P-CK, CK5/6, EMA, S100 and CD1α （partial positive expression）, Ki-67 （40%）, and PD-L1 （50%）, and negative for P40, Melan-A, and CEA. The proliferative lymphocytes around the tumor cells were diffuse positive for LCA, and the lymphocytes in and around the cancer nest were mainly CD3 positive T lymphocytes. EBER in situ hybridization of tumor cells was negative. Conclusion LECS on the check is very rare, and its pathological morphology and immunohistochemical phenotype are similar to those in other sites. EBER examination is valuable in differential diagnosis. Local complete resection is the first choice for the treatment of the tumor, and the prognosis is relatively good.

Key words: Lymphoepithelioma-like carcinoma, Skin, Immunohistochemistry, Diagnosis