新型冠状病毒变异株对新型冠状病毒疾病诊治及防疫的影响分析

doi:10.3969/j.issn.2095-378X.2021.03.013

Abstract

Abstract: Multiple variants of SARS-CoV-2 have appeared in many countries across the world and resulted in the gradual enhancement of viral transmission and infection. Recently, Delta variant invaded China and caused serious consequences. The continuous mutation of SARS-CoV-2 is turning into a critical topic of global pandemic control. By summarizing the studies of typical variants, this article analyzed the impacts of SARS-CoV-2 variants on diagnosis, treatment, and vaccination from the perspective of biology, and discussed the strategies on how to tackle the challenge of the continuous mutation.

Key words: SARS-CoV-2, Variant, Mutation, Diagnosis, Treatment, Vaccine, Pandemic control

CLC Number:

R183.3

ZHANG Ke, SHEN Jie, HU Lihua. Impacts of SARS-CoV-2 variants on diagnosis, treatment, and control of COVID-19[J]. Surgical Research and New Technique, 2021, 10(3): 203-208.

References

[1] Kim D, Lee J Y, Yang J S, et al.The architecture of SARS-CoV-2 transcriptome[J]. Cell, 2020,181(4):914-921.
[2] Ferron F, Subissi L, De Morais A T S, et al. Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus rna[J]. PNAS, 2018,115(2):E162-E171.
[3] Gerhard W, Mozdzanowska K, Zharikova D.Prospects for universal influenza virus vaccine[J]. Emerg Infect Dis, 2006,12(4):569-574.
[4] Laffeber C, Koning K D, Kanaar R, et al.Experimental evidence for enhanced receptor binding by rapidly spreading SARS-CoV-2 variants[J]. J Mol Biol, 2021,433(15):167058.
[5] Xie X, Liu Y, Liu J, et al.Neutralization of SARS-CoV-2 spike 69/70 deletion, e484k and n501y variants by bnt162b2 vaccine-elicited sera[J]. Nat Med, 2021,27(4):620-621.
[6] Collier D A, De M A, Ferreira I A, et al.Sensitivity of SARS-CoV-2 b.1.1.7 to mrna vaccine-elicited antibodies[J]. Nature, 2021,593(7857):136-141.
[7] Campbell F, Archer B, Laurenson-Schafer H, et al.Increased transmissibility and global spread of SARS-CoV-2 variants of concern as at June 2021[J]. Eurosurveillance, 2021,26(24):1-6.
[8] Deng X, Garcia-Knight M A, Khalid M M, et al. Transmission, infectivity, and neutralization of a spike l452r SARS-CoV-2 variant[J]. Cell, 2021,184(13):3426-3437.
[9] Zhou B, Thao T T N, Hoffmann D, et al. SARS-CoV-2 spike d614g change enhances replication and transmission[J]. Nature, 2021,592(7852):122-127.
[10] 杨梅,张晓天,刘秀敏,等.新型冠状病毒检测方法的应用现状[J]. 中国实验诊断学, 2020,24(7):1204-1207.
[11] Karim S, Oliveira T D.New SARS-CoV-2 variants-clinical, public health, and vaccine implications[J]. New Engl J Med,2021,384(19):1866-1868.
[12] Sadoff J, Gray G, Vandebosch A, et al.Safety and efficacy of single-dose Ad26. Cov2. S vaccine against COVID-19[J]. New Engl J Med, 2021,384(23):2187-2201.
[13] Lopez Bernal J, Andrews N, Gower C, et al.Effectiveness of COVID-19 vaccines against the b.1.617.2 (delta) variant[J]. New Engl J Med, 2021,385(7):585-594.
[14] Emary K R, Golubchik T, Aley P K, et al.Efficacy of chadox1 nCOV-19 (azd1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (b.1.1.7): An exploratory analysis of a randomised controlled trial[J]. The Lancet, 2021,397(10282):1351-1362.
[15] Wang P, Nair M S, Liu L, et al.Antibody resistance of SARS-CoV-2 variants b.1.351 and b.1.1.7[J]. Nature, 2021,593(7857):130-135.
[16] Edara V V, Norwood C, Floyd K, et al.Infection-and vaccine-induced antibody binding and neutralization of the b.1.351 SARS-CoV-2 variant[J]. Cell Host Microbe, 2021,29(4):516-521.
[17] Shen X, Tang H, McDanal C, et al. SARS-CoV-2 variant b.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral spike vaccines[J]. Cell Host Microbe, 2021,29(4):529-539.
[18] Hoffmann M, Arora P, Groß R, et al.SARS-CoV-2 variants b.1.351 and p.1 escape from neutralizing antibodies[J]. Cell, 2021,184(9):2384-2393.
[19] Kuzmina A, Khalaila Y, Voloshin O, et al.SARS-CoV-2 spike variants exhibit differential infectivity and neutralization resistance to convalescent or post-vaccination sera[J]. Cell Host Microbe, 2021,29(4):522-528.
[20] 穆鑫,赵颖,张兰,等.我国治疗新冠肺炎药物临床研究现状浅析[J]. 中国临床药理学与治疗学, 2020,25(8):869-877.
[21] Weinreich D M, Sivapalasingam S, Norton T, et al.Regn-cov2, a neutralizing antibody cocktail, in outpatients with COVID-19[J]. New Engl J Med, 2021,384(3):238-251.
[22] Hansen J, Baum A, Pascal K E, et al.Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail[J]. Science, 2020,369(6506):1010-1014.
[23] Kidd M, Richter A, Best A, et al.S-variant SARS-CoV-2 lineage b1. 1.7 is associated with significantly higher viral load in samples tested by taqpath polymerase chain reaction[J]. J Infect Dis, 2021,223(10):1666-1670.
[24] Rockx B, Kuiken T, Herfst S, et al.Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model[J]. Science, 2020,368(6494):1012-1015.
[25] Vogel G.Mixing vaccines may boost immune responses[J]. Science, 2021,372(6547):1138.
[26] Andersen K G, Rambaut A, Lipkin W I, et al.The proximal origin of SARS-CoV-2[J]. Nat Med, 2020,26(4):450-452.
[27] Zhou P, Yang X L, Wang X G, et al.A pneumonia outbreak associated with a new coronavirus of probable bat origin[J]. Nature, 2020,579(7798):270-273.
[28] Li W.Bats are natural reservoirs of SARS-like coronaviruses[J]. Science, 2005,310(5748):676-679.
[29] Azhar E I, El-Kafrawy S A, Farraj S A, et al. Evidence for camel-to-human transmission of MERS coronavirus[J]. New Engl J Med, 2014,370(26):2499-2505.
[30] Shi J, Wen Z, Zhong G, et al.Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2[J]. Science, 2020,368(6494):1016-1020.

Impacts of SARS-CoV-2 variants on diagnosis, treatment, and control of COVID-19

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	WANG Qian, ZHU Xuyou, ZHANG Haoyang, SUN Heguo, LI Jia, GAO Qingyun, YI Xianghua. Lymphoepithelioma-like carcinoma of the skin： A case report and literature review [J]. Surgical Research and New Technique, 2022, 11(1): 51-55.
[2]	ZHANG Xiaolin, JIN Ling. Clinical analysis of 36 cases with external auditory canal cholesteatoma [J]. Surgical Research and New Technique, 2021, 10(4): 273-276.
[3]	ZOU Zhuan, HE Wenbao, LI Bing, ZHAO Youguang, ZHOU Haichao, YANG Yunfeng. Percutaneous reduction and cannulated screw fixation for treatment of the fifth metatarsal base avulsion fractures [J]. Surgical Research and New Technique, 2021, 10(2): 97-100.
[4]	LIU Nanbin, XU Yan, WEI Yuhua, LIU Zhongyan, CHEN Quanning, SHI Baomin. Analysis on diagnosis and treatment of 39 cases of acute gangrenous cholecystitis [J]. Surgical Research and New Technique, 2021, 10(1): 37-41.
[5]	YUAN Xun, GU Zehua, SHAO Lei. Coronavirus nucleic acid testing equipment configuration in hospital during the Covid-19 pandemic [J]. Surgical Research and New Technique, 2020, 9(4): 280-286.
[6]	LIU Nanbin, WU Gang, BIAN Cuidong. Diagnosis and treatment of 12 cases of tape bladder invasion after TVT-O operation [J]. Surgical Research and New Technique, 2020, 9(3): 154-157.
[7]	XU Yan, LIU Nanbin. Clinical dilemma of xanthogranulomatous cholecystitis [J]. Surgical Research and New Technique, 2020, 9(3): 197-200.
[8]	LI Chuangkun, HUANG Yingfeng, ZOU Liaonan, LI Xiaoying, LUO Jie, NIU Feng, ZHAO Risheng, WANG Huaiming, WANG Hui, HUANG Rongkang. Application value of fecal SDC2 gene methylation test in early colorectal tumor diagnosis [J]. Surgical Research and New Technique, 2020, 9(1): 10-13.
[9]	GU Li, YU Lei, ZHANG Yiqian, WANG Xinli. One case of Madelung's disease [J]. Surgical Research and New Technique, 2020, 9(1): 59-62.
[10]	ZHU Xuyou, SHI Juanhong, YI Xianghua, ZHANG Ziqiang, ZHENG Shaoqiang, ZHANG Long, LIU Yuting, ZENG Yu, HAN Hongxiu, FANG Xia. Diagnostic value of transbronchial frozen lung biopsy in interstitial lung disease [J]. Surgical Research and New Technique, 2019, 8(4): 248-252.
[11]	LIU Pengfei, XU Wen, LIU Kai, YE Chun. Differential diagnosis between atypical hepatic abscess and hepatocellular carcinoma [J]. Surgical Research and New Technique, 2019, 8(3): 187-188.
[12]	YI Lina, ZOU Jue, XIAO Feng, YANG Yelin, LU Zhicheng, YAN Hongzhu. Myxopapillary ependymoma with extensive sacral destruction: a clinicopathologic analysis [J]. Surgical Research and New Technique, 2019, 8(3): 189-193.
[13]	LIU Pengfei, XU Wen, LIU Kai, YE Chun. Surgical experience of hepatic cyst connected with bile duct [J]. Surgical Research and New Technique, 2019, 8(2): 118-119.
[14]	PAN Jianhai, LI Zhongmin, WEN Li, WU Yang. Application of laparoscopy in surgical treatment of acute gangrenous appendicitis [J]. Surgical Research and New Technique, 2019, 8(1): 10-12.
[15]	XIN Guangyi, WANG Liping. Observation of endoscopic hemostasis treatment and nursing for acute non-varicose upper gastrointestinal bleeding [J]. Surgical Research and New Technique, 2018, 7(4): 288-291.