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Advances in systemic therapy of advanced renal cell carcinoma HU Qingyue, ZHAI Wei, ZHENG Junhua Surgical Research and New Technique    2023, 12 (4): 237-242.   DOI: 10.3969/j.issn.2095-378X.2023.04.001 Abstract （488）      PDF（pc） （1253KB）（744）       Knowledge map    Renal cell carcinoma is a common type of urinary cancer with insidious onset and rapid progression. Advanced renal cell carcinoma has poor prognosis and primarily depends on systemic therapy which mainly composed of targeted therapy and immunotherapy. Recently, new targeted drugs, immuno-targeted combination therapy, HIF-2α inhibitors, and probiotic combination therapy provide more possible options for the treatment. In this review, we gave an overview of the advances in systemic therapy of advanced renal cell carcinoma, aiming to help make clinical decisions. Reference | Related Articles | Metrics

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Research progress on graft selection in anterior cruciate ligament reconstruction FENG Jianhao, WANG Jiaqi Surgical Research and New Technique    2023, 12 (2): 125-130.   DOI: 10.3969/j.issn.2095-378X.2023.02.013 Abstract （407）      PDF（pc） （636KB）（652）       Knowledge map    Anterior cruciate ligament （ACL） is one of the most vulnerable structures during sports and an essential anterior stabilizing structure in the knee joint. ACL injury can impair a patient’s ability to move, and if not properly treated in time, it often results in serious adverse complications like meniscal and articular cartilage damage, and even traumatic osteoarthritis. Currently, ACL reconstruction is the standard treatment for ACL injury, and the choice of grafts has a significant impact on patients’ postoperative functional recovery and surgical success. Autografts are the most commonly used grafts and have the most stable efficacy, but they have drawbacks like limited sources and donor-site morbidity. Although having greater adaptability, allografts carry a risk of immune rejection and the spread of diseases. Artificial ligaments are appropriate for those who must quickly resume their athletic activities, but they are technically challenging and have not been shown to be long-term effective. Due to the numerous issues with traditional grafts, recent rapid advancements in tissue engineering techniques are generating novel ideas for ACL reconstruction. In order to aid in the treatment of ACL injury, this article discussed the benefits, drawbacks, and clinical effectiveness of different grafts used in ACL reconstruction. Reference | Related Articles | Metrics

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Progress in the treatment of lunate fracture ABUDUREYIMU Abudukeremu, JI Jiaqing, YIN Ziyue, QIAN Jikui, FAN Jian Surgical Research and New Technique    2024, 13 (1): 67-71.   DOI: 10.3969/j.issn.2095-378X.2024.01.017 Abstract （374）      PDF（pc） （1195KB）（301）       Knowledge map    Fractures of lunate bone are rare injuries of the wrist that are usually resulted from high-energy trauma and are typically accompanied by other carpal injuries, such as scaphoid bone, capitate bone, radial styloid, and distal radius fracture. Misdiagnosis,missed diagnosis or inappropriate treatment in clinical practice lead to a high nonunion rate of lunate fractures, which often affects the movement of the wrist and even leads to complications such as osteonecrosis or loss of wrist function. The potential pathogenesis, therapeutic method,and prognosis of lunate fractures are still controversial. This article reviewed domestic and foreign literature on the classification, imaging characteristics and treatment methods from the perspectives of anatomical characteristics and injury mechanism of the lunate, so as to provide guidance for improving the prognosis of lunate fractures. Reference | Related Articles | Metrics

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Recent advances on diagnosis and treatment of massive rotator cuff tears XU Hui, JIANG Xiping, HU Qingxiang, HE Yaohua Surgical Research and New Technique    2024, 13 (1): 1-6.   DOI: 10.3969/j.issn.2095-378X.2024.01.001 Abstract （372）      PDF（pc） （1203KB）（879）       Knowledge map    Rotator cuff tear is a common shoulder disease, especially among athletes and middle-aged and elderly individuals. With the accelerating trend of aging population, the number of patients with rotator cuff tears is increasing. For massive rotator cuff tears, there is a high risk of re-tear after surgery and poor prognosis, which poses a significant clinical challenge. In recent years, surgical techniques for massive rotator cuff tears have continued to innovate, including superior capsule reconstruction, subacromial balloon spacer implantation, tendon transfer, and reverse shoulder arthroplasty. This article summarized the biomechanical effects of massive rotator cuff tears on the shoulder joint and focused on the latest treatment advancements, aiming to provide new reference for clinical treatment. Reference | Related Articles | Metrics

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History and development of laparoscopic pancreaticoduodenectomy LIU Jiangxi, WANG Yufeng, DING Yue, ZHU Ying, LI Kun Surgical Research and New Technique    2024, 13 (1): 72-75.   DOI: 10.3969/j.issn.2095-378X.2024.00.001 Abstract （316）      PDF（pc） （1178KB）（394）       Knowledge map    Laparoscopic pancreaticoduodenectomy （LPD） is one of the most complex and risky operations in pancreatic surgery. LPD was once neglected due to high morbidity and mortality, but with the advancement of laparoscopic instruments and the improvement of surgical protocols, LPD has returned to the favor of surgeons. This paper focused on the history and development of LPD. Reference | Related Articles | Metrics

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Impact of virtual reality technology on cognitive impairment and daily living ability of patients in rehabilitation treatment of hemiplegia after stroke GAO Hanlu, LIN Na Surgical Research and New Technique    2024, 13 (2): 110-114.   DOI: 10.3969/j.issn.2095-378X.2024.02.006 Abstract （251）      PDF（pc） （1487KB）（286）       Knowledge map    Objective To explore the impact of virtual reality technology on cognitive impairment and daily living ability of patients in the rehabilitation treatment of hemiplegia after stroke. Methods A total of 80 patients with post-stroke hemiplegia who received treatment from September 2021 to March 2023 were selected as research subjects and randomly devided into two groups, namely the conventional group and the virtual technology group, with 40 cases in each group. The former received a conventional rehabilitation training plan, while the latter used virtual reality technology on the basis of the conventional rehabilitation training plan. The scores of the Montreal cognitive assessment scale （MoCA） and the activities of daily living （ADL） ability were compared between the two groups before and after 8 weeks of treatment. Results After the intervention, the MoCA and ADL scores of the virtual technology group were significantly higher than those of the conventional group （P<0.05）. Conclusion Virtual reality technology can effectively alleviate cognitive impairment and enhance patients' daily living abilities in the rehabilitation treatment of hemiplegia after stroke. Reference | Related Articles | Metrics

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New progression in the treatment of hepatocellular carcinoma with portal vein tumor thrombosis LOU Zhenbang, WANG Kang, CHENG Yuqiang, YU Hongming, CHENG Shuqun Surgical Research and New Technique    2023, 12 (3): 157-162.   DOI: 10.3969/j.issn.2095-378X.2023.03.001 Abstract （237）      PDF（pc） （1347KB）（545）       Knowledge map    Portal vein tumor thrombus is a typical clinical manifestation of advanced hepatocellular carcinoma（HCC）, and it is also the main cause of death. In recent years, the idea and strategy of diagnosis and treatment of HCC complicated with portal vein tumor thrombosis have changed greatly with the successive use of targeted therapy and immunotherapy, such as the classification and staging of portal vein tumor thrombus, the process of multidisciplinary diagnosis and treatment, and the combination of comprehensive treatment. Reference | Related Articles | Metrics

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Effect of extracorporeal shock wave lithotripsy on renal calculi and risks factors of surgical failure YANG Haisheng Surgical Research and New Technique    2023, 12 (3): 176-179.   DOI: 10.3969/j.issn.2095-378X.2023.03.005 Abstract （229）      PDF（pc） （1203KB）（298）       Knowledge map    Objective To explore the therapeutic effect of extracorporeal shock wave lithotripsy on renal calculi and the influencing factors of surgical failure. Methods A retrospective analysis was performed on 600 outpatients and inpatients with kidney stones admitted to our hospital from May 2016 to May 2022. All patients received extracorporeal shock wave lithotripsy and success rate was calculated. The observation group （n=476） and the control group （n=124） were divided according to whether the surgery was successful or not. The general data and the operation conditions of patients in the two groups were compared, and the independent factors affecting the failure of extracorporeal shock wave lithotripsy were analyzed. Results The success rate of primary lithotripsy was 79.33% in the 600 patients. The complication rate was 2.33%, and all patients improved significantly after anti-infection treatment. There was no significant difference between the two groups in terms of gender, age, history of stone surgery, average disease duration, hematuria, pain, hydronephrosis, and other clinical symptoms （P>0.05）; there was a significant difference between the two groups in terms of body mass index （BMI）, stone size, stone location, surgical position, number of impacts, and operator's working years （P<0.05）; there was no significant difference between the two groups in terms of surgical area and lithotripsy voltage （P>0.05）. The results of regression analysis showed that surgical position, stone size, and number of impacts were independent risk factors for failure of extracorporeal shock wave lithotripsy for kidney stone treatment （P<0.05）. Conclusion The success rate of extracorporeal shock wave lithotripsy for renal calculi is 79.33%, and it is safe. The factors associated with the failure of extracorporeal shock wave lithotripsy for renal calculi mainly include the surgical position, the size of the calculi, and the number of shocks. Therefore, clinically, patients with large stones should try to adopt supine position, and increase the number of shocks while ensuring the safety of patients, so as to further improve the success rate of extracorporeal shock wave lithotripsy. Reference | Related Articles | Metrics

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Application of medical consumables management robot in management of consumables in operating room WU Jing, WANG Hao Surgical Research and New Technique    2023, 12 (2): 137-140.   DOI: 10.3969/j.issn.2095-378X.2023.02.015 Abstract （218）      PDF（pc） （1123KB）（262）       Knowledge map    Objective With the expansion of hospital scale and the development of medical technology, the usage of consumables in operating rooms is increasing year by year, and the problems of consumables management are appearing. In order to solve these problems, there is an urgent need to explore a new method of consumables management. Methods A medical consumables management robot was introduced to consumables management process in operating rooms. Results Some achievements were made, and problems of manual management of consumables in operating rooms were solved. Conclusion The research has confirmed that the medical consumables management robot could lift the working efficiency of operating rooms, strengthen the closed-loop management of medical consumables in operating rooms, and improve the satisfaction of medical staff and patients. Reference | Related Articles | Metrics

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Application of fluorescence imaging in urology TANG Kairan, HAN Bangmin Surgical Research and New Technique    2023, 12 (2): 81-85.   DOI: 10.3969/j.issn.2095-378X.2023.02.001 Abstract （209）      PDF（pc） （574KB）（513）       Knowledge map    Fluorescence-guided surgery （FGS） is a technique that is applied in clinical practice progressively, especially in the field of urology, due to the advantages of high resolution, safety, and operability. The review is aimed at explaining the basic principles and development history of FGS, and discussing current status and prospects of fluorescent tracers in urology. The emerging technology of FGS can help effectively improve the accuracy of surgical resection of lesions while reduce postoperative adverse effects, contributing to achieving the goal of precision medicine. Reference | Related Articles | Metrics

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Impact of laparoscopic fallopian tube fenestration and embryo retrieval surgery on ovarian reserve function and re-pregnancy in patients with ectopic pregnancy LI Miaoli, LIAN Lishan Surgical Research and New Technique    2023, 12 (4): 273-275.   DOI: 10.3969/j.issn.2095-378X.2023.04.010 Abstract （203）      PDF（pc） （1244KB）（288）       Knowledge map    Objective To analyze the clinical efficacy of laparoscopic fallopian tube fenestration and embryo retrieval surgery for ectopic pregnancy， and to explore its impact on ovarian reserve function and re-pregnancy in patients. Methods A total of 86 patients with ectopic pregnancy admitted from January 2020 to January 2023 were selected as research subjects， and divided into a control group （odd number） and an observation group （even number） with 43 patients in each group， based on their admission numbers. The control group underwent salpingectomy on the affected side， while the observation group underwent laparoscopic fenestration and embryo retrieval. The levels of serum anti-Mullerian hormone before and after surgery， the number of postoperative sinus follicles after surgery， and the rate of postoperative re-pregnancy were compared between the two groups of patients. Results Before surgery， there was no statistically significant difference in serum levels of anti-Mullerian hormone between the two groups of patients of different age groups （P>0.05）. At 3 months after surgery， the serum levels of anti-Mullerian hormone in the observation group aged 20-30 and 31-35 years were higher than those in the control group （P<0.05）. At 6 months after surgery， there was no statistically significant difference in the serum levels of anti-Mullerian hormone between the two groups of patients aged 20-30 and 31-35 years （P>0.05）. The number of sinus follicles in the observation group was higher than that in the control group at 3 and 6 months after surgery （P<0.05）. The intrauterine pregnancy rate in the observation group was higher than that in the control group at 12 months after surgery， and the infertility rate was lower （P<0.05）. Conclusion Laparoscopic fallopian tube fenestration and embryo retrieval surgery can protect ovarian reserve function and reproductive function in patients with ectopic pregnancy， and help improve the rate of intrauterine re-pregnancy after surgery. Reference | Related Articles | Metrics

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Expression and correlation of sFlt-1 and PlGF in placenta of patients with preeclampsia ZHOU Wenli, WANG Caili, KANG Wei, FENG Caixia Surgical Research and New Technique    2024, 13 (2): 96-100.   DOI: 10.3969/j.issn.2095-378X.2024.02.003 Abstract （199）      PDF（pc） （1492KB）（373）       Knowledge map    Objective To investigate the expression and correlation of soluble FMS-like tyrosine kinase-1 （sFlt-1） and placental growth factor （PlGF） in placenta of patients with preeclampsia. Methods The maternal placenta during delivery and clinical data of 10 patients with preeclampsia （study group） and 12 normal pregnant women （control group） were collected and retrieved, who gave birth in our hospital from August 2021 to December 2022. The expression of sFlt-1 and PlGF in placental tissue was detected by Western blotting （WB）. Results Compared with the control group, there was no significant difference in the age and body mass index of pregnant women in the study group （P>0.05）. Urine protein was negative in the control group and positive in the study group. The gestational age and neonatal weight in the study group were significantly lower than those in the control group （P<0.01）. Systolic blood pressure and diastolic blood pressure in the study group were significantly higher than those in the control group （P<0.01）. WB detection showed that compared with the control group, the expression level of sFlt-1 in placental tissue of the study group was significantly higher than that of the control group （Z=–3.962, P<0.01）. The expression level of PlGF in the study group was significantly lower than that in the control group （Z=–3.957, P<0.01）. Conclusion The increase of anti-vascular factor sFlt-1 expression and the decrease of pro-angiogenic factor PlGF in placental tissue of preeclampsia patients abnormally regulate vasomotor contraction and relaxation and participate in the occurrence, development, and target organ damage of preeclampsia. Reference | Related Articles | Metrics

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Treatment strategies for eyelid disease associated with thyroid eye disease WANG Huixue, YI Lan, JI Jiali, CHEN Qian, QIU Qinghua Surgical Research and New Technique    2024, 13 (2): 91-95.   DOI: 10.3969/j.issn.2095-378X.2024.02.001 Abstract （197）      PDF（pc） （1200KB）（400）       Knowledge map    Thyroid eye disease （TED） is the most common orbital disease in adults, and it is an organ-specific autoimmune inflammation closely related to thyroid disease. The clinical manifestations of TED are complex, including abnormal eyelid position such as eyelid recession and ptosis in one or both eyes. Severe eyelid recession can lead to exposed corneal ulcers. For TED eyelid complications, drug or surgical treatment is performed according to disease progression to reconstruct the patient's ocular surface appearance and achieve anatomical and social function reduction. Reference | Related Articles | Metrics

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Cost-benefit analysis of disposable visible bronchoscopes based on multiple centers YANG Kun, SHAO Lei Surgical Research and New Technique    2023, 12 (4): 300-301.   DOI: 10.3969/j.issn.2095-378X.2023.04.016 Abstract （197）      PDF（pc） （1138KB）（284）       Knowledge map    By comparing existing conventional reusable bronchoscopes and disposable visible bronchoscopes in multicenter intensive care units, this study conducted a cost-benefit analysis on disposable visual bronchoscopes from a series of cost issues such as procurement cost, clinical use effect, cleaning and disinfection, and the occurrence of cross infection. Reference | Related Articles | Metrics

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MR T2WI combined with DWI for preoperative staging of rectal cancer and its correlation with pathology WANG Chengli, DENG Na, YANG Cuiting, HAN Xiaobing, DU Kailing, PENG Weisheng Surgical Research and New Technique    2024, 13 (2): 130-133.   DOI: 10.3969/j.issn.2095-378X.2024.02.010 Abstract （195）      PDF（pc） （1263KB）（237）       Knowledge map    Objective To study the value of magnetic resonance （MR） T2 weighted imaging （T2WI） combined with diffusion weighted imaging （DWI） in preoperative staging of rectal cancer and its correlation with pathology. Methods This retrospective analysis was conducted on 208 patients of rectal cancer with complete imaging and pathological data from June 2020 to June 2023. All patients underwent preoperative rectal standard protocol of MRI examination, with plain and enhanced scans indicating the location and size of the tumor and DWI signals measuring the apparent diffusion coefficient （ADC） value of the tumor. We compared the diagnostic efficacy of T2WI alone and the combination of T2WI and DWI, obtained the average and minimum ADC values of tumor tissues with different pathological grades, and analyzed the correlation between the two values and pathological grades. Results The diagnostic accuracy of combined T2WI and DWI for T2 and T3 stages of rectal cancer was significantly higher than that of T2WI alone （P<0.05）. The average and minimum ADC values of low differentiated rectal cancer were significantly lower than those of medium and high differentiated rectal cancers （P<0.05）, and the minimum ADC value was negatively correlated with pathological grade（r=–0.422, P<0.05）. Conclusions The combination of T2WI and DWI has a higher diagnostic efficiency for rectal cancer than T2WI alone. In addition, the minimum ADC value has a good value for preoperative pathological grading of tumors. Reference | Related Articles | Metrics

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Effects of combined anterior and posterior segment surgery for macular hole combined with cataract on visual acuity, macular area morphology, and safety in patients ZHOU Yiling Surgical Research and New Technique    2023, 12 (4): 262-265.   DOI: 10.3969/j.issn.2095-378X.2023.04.007 Abstract （193）      PDF（pc） （3220KB）（273）       Knowledge map    Objective To investigate the effects of combined anterior and posterior segment surgery for macular hole combined with cataract on patients' vision， macular area morphology， and safety. Methods A total of 150 patients with macular hole combined with cataract treated in our hospital from April 2019 to April 2022 were selected as study subjects， and underwent combined anterior and posterior segment surgery. The visual acuity and changes in the morphology and structure of macular area of patients were compared before and after treatment， and the occurrence of postoperative complications was recorded. Results After treatment， the patients' visual acuity was higher than before treatment， and the intraocular pressure level was lower than before treatment （P<0.05）. The distortion of macular area morphology and structure in 146 patients was restored， with a recovery rate of 97.33%. The total incidence rate of complications was 7.33%. Conclusion The combined anterior and posterior segment surgery for macular hole combined with cataract has a definite therapeutic effect， can actively improve visual acuity and macular area morphology， and is relatively safe. It is worth promoting and applying in clinical practice. Reference | Related Articles | Metrics

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Treatment of 5 cases of trauma combined with seawater immersion and literature review CHEN Hongjie, WEI Liangfeng, ZHANG Hao, WANG Shousen Surgical Research and New Technique    2024, 13 (1): 35-38.   DOI: 10.3969/j.issn.2095-378X.2024.01.008 Abstract （190）      PDF（pc） （5699KB）（318）       Knowledge map    Objective To summarize the treatment results of trauma combined with seawater immersion, and to explore effective treatment methods for this injury. Methods The cases of trauma combined with seawater immersion admitted to our hospital from June 2020 to July 2023 were retrospectively analyzed, and the therapeutic effects were summarized and compared with literature reports. Results All the 5 patients were male. They were aged 26, 23, 24, 25, and 49, respectively. The wounds of all 5 patients healed in the first stage and the prognosis was good. Conclusion Trauma combined with seawater immersion is complicated. However, early rapid withdrawal from seawater, complete debridement, prevention of infection, rewarming, and necessary surgical intervention can significantly improve the prognosis. Reference | Related Articles | Metrics

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Clinical value of diquafosol sodium combined with sodium hyaluronate for patients with dry eye after cataract surgery LIU Yang Surgical Research and New Technique    2023, 12 (3): 180-183.   DOI: 10.3969/j.issn.2095-378X.2023.03.006 Abstract （188）      PDF（pc） （1209KB）（660）       Knowledge map    Objective To investigate the clinical value of diquafosol sodium combined with sodium hyaluronate for patients with dry eye after cataract surgery. Methods In this study, 236 patients with dry eye after cataract surgery, who were treated with diquafosol sodium and sodium hyaluronate in our hospital from January 2022 to January 2023, were selected as the combined group, at the same time, 82 patients with dry eye after cataract surgery treated with sodium hyaluronate alone were selected as the single therapy group, and the therapeutic effects of the two groups were compared and analyzed. Results The total effective rate of the combined group was significantly higher than that of the single therapy group （P<0.05）. There was no significant difference in SPEED score, Fluorescent Test （FL）, Tear Breakup Time （BUT）, and Schirner Test （Slt） between the two groups before treatment （P>0.05）. After treatment, the SPEED score, FL, BUT, and Slt in both groups were significantly improved （P<0.05）, and the scores of SPEED, FL, BUT, and Slt in the combined group were significantly better than those in the single therapy group （P<0.05）. There was no significant difference in the incidence of adverse reactions between the two groups （P>0.05）. Conclusion Compared with sodium hyaluronate alone, the combination of sodium hyaluronate and diquafosol sodium can significantly improve the therapeutic effect on dry eye after cataract surgery. Reference | Related Articles | Metrics

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Clinical efficacy of small incision negative pressure drainage combined with irrigation on perianal abscess and its impact on patient complications and quality of life LIU Jiarong, LIU Yongning, ZENG Chengyong Surgical Research and New Technique    2023, 12 (3): 189-191.   DOI: 10.3969/j.issn.2095-378X.2023.03.008 Abstract （188）      PDF（pc） （1213KB）（284）       Knowledge map    Objective To explore the clinical effect of small incision negative pressure drainage combined with irrigation treatment on perianal abscess. Methods A total of 100 patients with perianal abscess from January 2021 to June 2021 were selected and divided into a combined group and a conventional group according to the patient's choices, with 50 patients in each group. The combined group received small incision negative pressure drainage combined with irrigation treatment, while the conventional group received incision drainage treatment. Comparisons were made in the treatment outcomes, quality of life scores before and 4 weeks after surgery, and the incidence of complications 6 months after surgery between the two groups of patients. Results The total effective rate of the combined group （94.00%） was higher than that of the conventional group （78.00%） （P<0.05）. After surgery, the WHO QOL-BREF scores of both groups of patients were improved compared to before surgery, and the combined group scored higher than the conventional group （P<0.05）; The total incidence of complications in the combined group （2.00%） was lower than that in the conventional group （16.00%） （P<0.05）. Conclusion Small incision negative pressure drainage combined with irrigation treatment can effectively improve clinical treatment effectiveness, reduce complications, and improve patient quality of life for patients with perianal abscess. Reference | Related Articles | Metrics

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Effects of Mammotome breast minimally invasive rotary resection on benign breast tumors and aesthetic appearence ZHENG Lei Surgical Research and New Technique    2023, 12 (3): 168-170.   DOI: 10.3969/j.issn.2095-378X.2023.03.003 Abstract （186）      PDF（pc） （1224KB）（355）       Knowledge map    Objective To investigate the effects of Mammotome breast minimally invasive rotary resection on breast benign tumor and aesthetic appearence. Methods A total of 110 female patients with benign breast tumors admitted from August 2019 to January 2022 were selected as study subjects, and the patients were divided into the Mammotome group and the control group （55 cases each） according to the random number table method. The control group was given traditional breast tumor surgical treatment, and the Mammotome group was given Mammotome breast minimally invasive rotational treatment to observe the treatment effect and aesthetic changes. Results All patients completed the operation, and no serious complications occurred. The postoperative hospital stay and intraoperative blood loss in the Mammotome group were significantly reduced compared with the control group, and the difference in surgical time was not statistically significant （P>0.05）. The complication rates of incisional hematoma, incisional infection, and venous thrombosis at 1 month after surgery in the Mammotome group was lower than those in the control group （P<0.05）. The aesthetic effect scores such as breast shape, nipple sensation, and pigmentation at 1 month after surgery were higher in the Mammotome group than in the control group （P<0.05）. Conclusion Mammotome minimally invasive rotary resection can reduce the intraoperative bleeding and postoperative hospital stay, improve the beauty effects, reduce the occurrence of complications of patients with breast benign tumor, the rate of axillary lymph node metastasis and distant metastasis were decreased. Reference | Related Articles | Metrics