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The preliminary study of apoptosis and calcium metabolism in human colorectal cancer cells HCT 8 treated with Bufalin Surgical Research and New Technique    2016, 5 (4): 225-228.   Abstract （332）      PDF（pc） （2267KB）（2181）       Knowledge map    Objective：To study the influence and mechanism of bufalin on apoptosis and calcium metabolism in human colorectal cancer cell HCT 8. Methods：We used the method of CCK-8 to detect the proliferation of HCT 8 treated with bufalin of different concentrations at 24 hours or the same one at different time. And then , the apoptosis of the cell with different concentrations was detected by Annexin V / PI double staining apoptosis kit. Finally, we investigated the effect of different concentrations of bufalin on intracellular Ca2 + by using Ca2+ fluorescence probe Fluo-3 AM to mark its intracellular Ca2+. Results：The inhibition of human colorectal cancer cell HCT 8 with bufalin showed dose and time dependent manner obviously by the method of CCK-8. The result of apoptosis with flow cytometry illustrated that bufalin can induce apoptosis in the cell HCT 8, and represented a dose-dependent manner. According to the results of the intracellular Ca2+ labeled by calcium fluorescent probe calcium, there was a higher concentration of intracellular calcium when the cell treated at a higher concentration of bufalin. Conclusion：Bufalin can induce apoptosis in the cell of HCT 8, and it may be related to the metabolism of intracellular Ca2+. Reference | Related Articles | Metrics

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Research progress of the treatment of dislocation of peroneal tendons YU Yao-ping, YU Guang-rong 外科研究与新技术    2013, 2 (2): 123-127.   Abstract （397）      PDF（pc） （754KB）（1869）       Knowledge map    Peroneal tendons dislocation refers to slip the external ankle peroneal tendons in the rear of the fibula groove,inducing a series of symptoms such as instability and pain in the external ankle.There are variously different surgical methods of treating the dislocation of peroneal tendons,each with distinct characteristics.Operation styles mostly consist of soft tissue repair,fibular groove deepening,fibular osteotomy,tissue graft,peroneal tendons rerouting and using of endoscopy in treatment of dislocation.The method of treating peroneal tendons dislocation depend on injury mechanism and patients individual condition for achieving high healing rate,less complications and rapid recovery. Reference | Related Articles | Metrics

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Clinical application of metal catheter placement of super smooth interventional guidewire for catherization in male dysuria MAO Fuyong, ZENG Ronghua, ZHOU Lu, SHAN Fayong, LI Pingping Surgical Research and New Technique    2020, 9 (2): 88-90.   DOI: 10.3969/j.issn.2095-378X.2020.02.005 Abstract （226）      PDF（pc） （1575KB）（1737）       Knowledge map    Objective To investigate the feasibility of catheterization with a super smooth interventional guidewire combined with a metal catheter and a conventional catheter for male patients who failed conventional catheterization. Methods A total of 205 male patients who failed conventional catheterization were treated with a super smooth interventional guidewire combined with a metal catheter and a conventional catheter. Results Of the 205 patients, 202 had successful catheterization and 3 failed. The success rate of primary catheterization was 98.53%, and the failure rate was 2.47%. Conclusion The use of super smooth interventional guidewire combined with metal catheter for catheterization is a simple, safe, and highly successful method, which is worthy of promotion in clinical practice. Reference | Related Articles | Metrics

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Research progress on the morphology of corneal endothelial cells DU Fei, BI Yan-long 外科研究与新技术    2013, 2 (2): 113-117.   Abstract （355）      PDF（pc） （692KB）（1620）       Knowledge map    The adult corneal endothelial cells (CEC) could not take self-renewal.The circumjacent cells enlarge and migrate to fill the vacancy after trauma.A normal endothelial cellular density and morphology are pivotal to maintain a normal corneal structure,transparency and refractive index.Traumas,surgeries and some metabolic problems may lead to irreversible results.In this review,the CEC morphological parameters,CEC function and redistribution in a variety of the situation were comprehensively reviewed.Hope it would provide a reference for the treatment of ocular diseases and the judgment of surgical prognosis. Reference | Related Articles | Metrics

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Clinical value of CT in diagnosis of acute appendicitis Surgical Research and New Technique    2015, 4 (2): 103-106.   Abstract （139）      PDF（pc） （1257KB）（1610）       Knowledge map    [Abstract] Objective To enhance the application value of CT in diagnosis of acute appendicitis. Methods CT findings of 87 cases with acute appendicitis confirmed by surgery and pathology were retrospectively analyzed. Results There were 87 cases of acute appendicitis，45 cases of simple appendicitis，28 cases of suppurative appendicitis，7 cases of gangrenous appendicitis，7 cases of appendiceal abscess. CT findings of 5 cases of simple appendicitis were negative. CT showed swelling of the appendix，edema of the appendix wall and the abscess of the appendix.Conclusion CT imaging is of great value in the diagnosis of acute appendicitis. Reference | Related Articles | Metrics

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Effects of modulated medium frequency electrotherapy and nursing interventions on postoperative adhesive intestinal obstruction GU Guihua, OUYANG Hua, ZHANG Xiongwen, LUO Min Surgical Research and New Technique    2020, 9 (2): 146-148.   DOI: 10.3969/j.issn.2095-378X.2020.02.020 Abstract （274）      PDF（pc） （1159KB）（1508）       Knowledge map    Objective To study the effects of modulated medium frequency electrotherapy and nursing interventions on postoperative adhesive intestinal obstruction. Methods A total of 42 adhesive intestinal obstruction patients treated from January 2017 to October 2019 in our hospital were selected and randomly assigned to two groups, with 21 cases in each group. The control group took routine therapy and nursing care; the observation group took medium frequency electrotherapy and comprehensive nursing interventions. Nursing effects between the two groups were probed. Results The exhaust time, initial bowel sound time, and gastrointestinal recovery time in the observation group were significantly shorter than those in the control group (P<0.05); the watery stool time and gastric fluid clearance time in the observation group were also shorter than those in the control group (P<0.05); the total effective rate in the observation group (95.24%) was significantly higher than the rate in the control group (76.19%， P<0.05). Conclusion Applying modulated medium frequency electrotherapy and nursing interventions to patients with postoperative adhesive intestinal obstruction can improve gastrointestinal function and treatment prognosis, showing significant clinical effects. Reference | Related Articles | Metrics

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Effectiveness of continuous improvement of rate of defibrillation monitors in good condition YIN Peng, HUANG Liang, CHEN Wen Surgical Research and New Technique    2020, 9 (2): 125-128.   DOI: 10.3969/j.issn.2095-378X.2020.02.015 Abstract （219）      PDF（pc） （1459KB）（1496）       Knowledge map    Objective To continuously improve the rate of defibrillation monitors in good condition, increase the success rate of clinical rescue, and protect people’s lives. Methods Through investigating current situation, setting goals, cause analysis, countermeasure formulation, countermeasure implementation, and effect evaluation, the rate of defibrillation monitors in good condition was detected. Results After two years of continuous improvement, the rate of defibrillation monitors in good condidtion reached 100%. Conclusion Clinical engineers can perfect their work through scientific approaches, and can better summarize their work experience and improve their ability to better serve clinical needs. Reference | Related Articles | Metrics

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Reseach progress on development of Barrett esophagus to esophageal adenocarcinoma YAO Liwen, XU Shuchang Surgical Research and New Technique    2020, 9 (2): 100-104.   DOI: 10.3969/j.issn.2095-378X.2020.02.009 Abstract （259）      PDF（pc） （1206KB）（1490）       Knowledge map    Barrett esophagus (BE) refers to the replacement of normal lamellar squamous epithelium in the lower esophagus by metaplasia of columnar epithelium. BE is the strongest risk for esophageal adenocarcinoma (EAC). The evolution and progression from BE to EAC has become the research focus of BE. Many key signaling factors and signaling pathways are involved. This paper reviewed the research progress on how BE evolves into EAC. Reference | Related Articles | Metrics

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Research progress on electroacupuncture-assisted anesthesia in thyroid surgery SHI Xiaowei, ZHU Junyong, PENG Sheng Surgical Research and New Technique    2020, 9 (2): 117-119.   DOI: 10.3969/j.issn.2095-378X.2020.02.013 Abstract （302）      PDF（pc） （1046KB）（1486）       Knowledge map    The anatomical structure around thyroid gland is complex as there are many important vessels and nerves. At present, the main anesthesia methods for thyroid surgery are local anesthesia, nerve block, and general anesthesia. This paper reviewed the role of auxiliary acupuncture in thyroid surgery under different anesthesia modes, and clarified the advantages of acupuncture in thyroid surgery, aiming to provide reference for the scientific research on improving the clinical efficacy of acupuncture-drug anesthesia. Reference | Related Articles | Metrics

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Application of Mulligan mobilisations with movement plus muscle energy techniques to cervical spondylotic radiculopathy TAN Yongsheng Surgical Research and New Technique    2020, 9 (2): 78-81.   DOI: 10.3969/j.issn.2095-378X.2020.02.002 Abstract （410）      PDF（pc） （1195KB）（1466）       Knowledge map    Objective To explore the application of Mulligan mobilisations with movement plus muscle energy techniques to cervical spondylotic radiculopathy (CSR). Methods A total of 86 CSR patients treated from February 2017 to February 2020 in our hospital were randomly assigned to two groups, with 43 cases in each group. The conventional group took conventional rehabilitation; the combined group took Mulligan mobilisations with movement and muscle energy techniques. Clinical assessment scale for cervical spondylosis (CASCS) scores, neck disability index (NDI) scores, active range of motion (AROM), Short-form 36 Health Survey Questionnaire (SF-36) scores, Visual Analogue Scale (VAS) scores, and muscle pressure pain threshold were compared before and after the treatment. Results The CASCS score, AROM, and SF-36 score were significantly higher and the NDI score and VAS score were significantly lower in the combined group than those in the conventional group (P<0.05). The pressure pain thresholds of trapezius, levator scapulae, and suboital muscles in the combined group were significantly lower than those in the conventional group (P<0.05). Conclusion Mulligan mobilisations with movement plus muscle energy techniques can relieve the clinical symptoms of cervical spondylosis, such as reducing neck disability, increasing the active range of motion, and reducing pain, and thereby improve the quality of life of patients. Reference | Related Articles | Metrics

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Safety control and nursing quality in operating rooms under checklist management during outbreak of coronavirus disease YAO Ying, QIAN Yingshan, TANG Ailin Surgical Research and New Technique    2020, 9 (2): 134-138.   DOI: 10.3969/j.issn.2095-378X.2020.02.017 Abstract （248）      PDF（pc） （1139KB）（1460）       Knowledge map    Objective To explore safety control measures and procedures for operating room checklist management during the outbreak of coronavirus disease 2019 (COVID-19), and to ensure the quality of surgical safety and nursing care not affected by the epidemic. Methods Based on the COVID-19 diagnosis and treatment plan, the COVID-19 prevention and control plan, and technical guidelines on the prevention and control of COVID-19 in medical institutions, nursing care tasks in operating rooms were detailed and quantified, and various checklists were formulated to define and improve surgical safety prevention and control measures and procedures in operating rooms. Results During the epidemic, surgeries were succefully performed according to the checklist items, and no safty problems of surgical nursing were found. The checklists identified the respective responsibilities of nurses, improved the working system and workflow during the epidemic, and ensured sufficient supplies of surgical protection materials. Conclusion During the COVID-19 epidemic, checklist management can effectively adjust the nursing measures in operating rooms and optimize workflow. While ensuring surgical operations, it can effectively implement epidemic prevention and control, and improve the work efficiency and quality in operating rooms compared with previous work. Reference | Related Articles | Metrics

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Thermal ablation in treatment of benign and malignant thyroid tumors： Current status and future perspectives ZHU Chenfang, CHEN Jiangbo, LIN Tingyu, FEI Jian Surgical Research and New Technique    2022, 11 (4): 221-226.   DOI: 10.3969/j.issn.2095-378X.2022.04.001 Abstract （416）      PDF（pc） （1179KB）（1456）       Knowledge map    In recent years the application of thermal ablation （TA） in the treatment of benign and malignant thyroid tumors has drawn wide attention. Many studies have shown that compared with traditional surgery, TA is a minimally invasive and cosmetic surgery. In particular, the safety and effectiveness of TA in the treatment of benign thyroid tumors have been generally proven, but are still controversial in the treatment of papillary thyroid microcarcinoma. This article reviewed related literature, and focused on the principles of different thermal ablation techniques, indications and contraindications for the treatment of benign and malignant thyroid tumors, the safety and effectiveness of TA, and the advantages and disadvantages of TA compared with traditional surgery. Reference | Related Articles | Metrics

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Research status and progress of non-tube percutaneous nephrolithotomy YU Guantian, LI Xuede Surgical Research and New Technique    2020, 9 (2): 114-116.   DOI: 10.3969/j.issn.2095-378X.2020.02.012 Abstract （257）      PDF（pc） （1021KB）（1449）       Knowledge map    Percutaneous nephrolithotomy (PCNL) has gradually replaced the traditional open surgery as the main surgical method for the treatment of upper urinary tract calculi. Indwelling nephrostomy tubes and ureteral stents after traditional PCNL bring many problems. At present, PCNL has two major development trends, minimally invasive and non-tube. Non-tube PCNL has the advantages of short hospitalization time, low cost, and high patient comfort. However, there is no concensus on the indications and contraindications of non-tube PCNL, and there are postoperative bleeding, urogenic sepsis, and other complications in non-tube PCNL. With the continuing research on non-tube PCNL, this paper reviewed relevant research status and progress. Reference | Related Articles | Metrics

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Efficacy and prognosis of craniotomy hematoma removal and drilling and drainage for patients with subdural hematoma LIN Qiyan, HE Yongchao, ZHANG Xiaofeng Surgical Research and New Technique    2020, 9 (2): 94-96.   DOI: 10.3969/j.issn.2095-378X.2020.02.007 Abstract （253）      PDF（pc） （1154KB）（1426）       Knowledge map    Objective To compare and analyze the symptoms of patients with chronic subdural hematoma treated with small bone window craniotomy hematoma removal and drilling and drainage, and the recurrence after surgery. Method A total of 85 patients with chronic subdural hematoma treated in our hospital from January 2014 to March 2020 were selected as study subjects, and divided into an observation group and a control group according to the treatment Methods provided. The observation group was treated with in-window craniotomy, while the control group was treated with drilling and drainage surgery. Comparisons of the symptoms and recurrence were made between of the two groups. Results There was no significant difference in symptom improvement between the two groups of patients after respective surgical treatments (P>0.05); there was also no significant difference in the incidence of complications after surgery between the two groups of patients. The observation group showed a significantly lower recurrence rate than the control group (P<0.05). Conclusion Both small bone window craniotomy hematoma removal and drilling and drainage have certain therapeutic effects on chronic subdural hematoma, and effectively alleviate patient’s symptoms. Small bone window craniotomy hematoma removal can produce a lower recurrence rate; therefore, it is worthy of popularization and application in clinical treatment. Reference | Related Articles | Metrics

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Clinical observation of 235 patients with unilateral inguinal hernia undergoing laparoscopic transabdominal preperitoneal prosthetic herniorrhaphy LI Guofeng Surgical Research and New Technique    2020, 9 (2): 85-87.   DOI: 10.3969/j.issn.2095-378X.2020.02.004 Abstract （224）      PDF（pc） （1178KB）（1382）       Knowledge map    Objective To observe the clinical efficacy of laparoscopic transabdominal preperitoneal prosthetic herniorraphy on unilateral inguinal hernia among 235 patients. Methods A total of 470 patients with unilateral inguinal hernia treated from March 2016 to February 2020 in our hospital were divided into a laparoscopic transabdominal preperitoneal prosthetic herniorraphy group (observation group) and an open tension-free inguinal hernia repair group (control group) according to different therapies, with 235 cases in each group. Operation conditions, postoperative recurrence rate and complications, and GQOL-74 (Generic Quality of Life Inventory-74) scores of the two groups were evaluated. Results No differences in preoperative VAS (Visual Analogue Scale) and GQOL-74 scores were observed between the two groups. The length of hospital stay [(5.45±0.85) d vs. (8.25±1.55)d], postoperative VAS scores (2.54±0.54 vs. 5.25±1.05), time of off?bed activity [(13.52±3.54) h vs. (45.42±4.02)h], postoperative complication rate (3.40% vs. 13.19%), and recurrence rate at 6 months after surgery (2.55% vs. 9.36%) in the observation group were all lower than those in the control group (all P<0.05), but the operative time [(73.42±4.36) min vs. (44.52±4.42) min] and postoperative GQOL-74 score were higher than those in the control group (all P<0.05). Conclusion Laparoscopic transabdominal preperitoneal prosthetic herniorraphy for unilateral inguinal hernia can produce higher life quality, less postoperational pain, shorter hospital stay, a lower recurrence rate, and fewer complications, thus it is worthy of application. Reference | Related Articles | Metrics

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Investigation and analysis on research ability of clinical medical students with standardized residency training XUAN Miao, WANG Wei, HU Yu, HUANG Lei, YANG Jun, ZHANG Jing, JIN Lingjing, CHENG Liming Surgical Research and New Technique    2020, 9 (2): 129-133.   DOI: 10.3969/j.issn.2095-378X.2020.02.016 Abstract （221）      PDF（pc） （1150KB）（1372）       Knowledge map    Objective To investigate and analyze the research ability of residents in Shanghai Tongji Hospital standardized residency training base. Methods An electronic questionnaire survey was condcuted among 68 residents in the standardized residency training base of Shanghai Tongji Hospital, which included basic information, research status, and research needs. Results Only 16.8% residents had undertaken scientific research projects, 55.88% residents had participated in scientific research projects, and 38.24% residents had scientific research outputs. More than 80% reported inadequate systematic scientific research training, but more than 60% were interested in scientific research work, and more than half of them were in urgent need of support in all aspects of scientific research. Conclusion In the selected hospital, 72.68% residents with standardized residency training have undertaken (16.8%) and participated in (55.88%) scientific research projects, and more than half of the residents show urgent need of support in all aspects of scientific research. It is suggested that residents focus on scientific research ability building， and schools and medical institutions give residents enough support in scientific research work to improve their scientific research ability and train them to become excellent doctors， teachers, and researchers in the future. Reference | Related Articles | Metrics

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Surgical Research and New Technique    2017, 6 (1): 60-64.   Abstract （252）      PDF（pc） （1147KB）（1358）       Knowledge map    Reference | Related Articles | Metrics

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Effects of standardized workflow of chest pain for nurses on treatment of emergent acute myocardial infarction and cardiac function LIANG Yecai, LI Minyan, LAI Yinghong Surgical Research and New Technique    2020, 9 (2): 142-145.   DOI: 10.3969/j.issn.2095-378X.2020.02.019 Abstract （251）      PDF（pc） （1300KB）（1357）       Knowledge map    Objective To evaluate the effects of standardized workflow of chest pain for nurses on the treatment of emergent acute myocardial infarction (AMI) and cardiac function. Methods A total of 120 AMI patients from March 2018 to March 2019 in our hospital were randomly divided into two groups, with 60 cases in each group. The control group was given routine nursing, while the observation group was given nursing care according to standardized workflow of chest pain. The success rate of AMI emergency treatment, as well as the time of the first electrocardiogram, venous access establishment, cTnT monitoring results, drug administration, family members signing informed consent, and ICU stay, were compared between the two groups; the left ventricular ejection fraction, NYHA grade of cardiac function, and the incidence of complications before and after nursing were also compared. Results The success rate of AMI emergency treatment in the observation group was significantly higher than that in the control group (P<0.05). After designed nursing care, the left ventricular ejection fraction and NYHA grade of the observation group were better than those of the control group (P<0.05). The time of the first electrocardiogram, venous access establishment, cTnT monitoring results, drug administration, family members signing informed consent, and ICU stay in the observation group were significantly shorter than those in the control group (P<0.05). The incidence rate of complications in the observation group was significantly lower than that in the control group (P<0.05). Conclusion The implementation of standardized workflow of chest pain for nurses to patients with AMI can achieve good treatment effects, shorten the time of nursing and rescue work, improve the success rate of rescue patients’ heart function, and reduce complications. Reference | Related Articles | Metrics

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Effect of percutaneous pedicle screw on thoracolumbar spinal fracture ZENG Bo, LIU Jinglong, LI Peihao, ZHUANG Jiehui, CAI Jundong, LI Zedian, LIN Jiehao Surgical Research and New Technique    2020, 9 (2): 82-84.   DOI: 10.3969/j.issn.2095-378X.2020.02.003 Abstract （176）      PDF（pc） （1211KB）（1326）       Knowledge map    Objective To investigate the effect of percutaneous pedicle screw on thoracolumbar spinal fracture. Methods A total of 326 patients with thoracolumbar spinal fractures treated in our hospital from January 2017 to September 2019 were randomly divided into two groups: traditional group (163 cases, treated with traditional open pedicle screw fixation) and minimally invasive group (163 cases, treated with percutaneous pedicle screw fixation). The effects of the two groups were compared. Results The amount of intraoperative bleeding in the minimally invasive group was significantly less than that in the traditional group (P<0.05), and there were no significant differences in operation time and excellent and good operation rate between the two groups (P>0.05). After treatment, the VAS and ODI scores of the two groups were significantly improved, and the scores after treatment in the minimally invasive group were significantly lower than those in the traditional group (P<0.05); the incidence rate of complications in the traditional group was significantly higher than that in the minimally invasive group (P<0.05). Conclusion The short-term effect of percutaneous pedicle screw fixation is similar to that of traditional open surgery, but it can significantly improve the recovery of postoperative thoracolumbar function and reduce postoperative pain and complications, which is worthy of clinical promotion. Reference | Related Articles | Metrics

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Research progress on circRNA and infectious diseases CHEN Xi, WU Denglong Surgical Research and New Technique    2020, 9 (2): 110-113.   DOI: 10.3969/j.issn.2095-378X.2020.02.011 Abstract （300）      PDF（pc） （1130KB）（1307）       Knowledge map    CircRNA is a kind of circular and closed-loop RNA. Because circRNA does not have 5′-end hat structure and 3′-end polyadenosine acidified tail structure, the expression of circRNA is more stable. As a hot spot in the field of RNA research, circRNA has been found to be associated with the occurrence of many diseases, including nervous system diseases, tumors, and diabetes. Infectious diseases refer to the local traumatic lesions and systemic inflammatory reactions related to impaired metabolic functions and tissue structures caused by the invasion, growth, and reproduction of bacteria, viruses, fungi, parasites and others in the human body. Current studies have proved that circRNA is associated with the occurrence of many infectious diseases. The paper reviewed the research progress on circRNA and infectious diseases. Reference | Related Articles | Metrics