一种潜在的骨肉瘤治疗靶向—TWEAK/Fn14信号通路

Abstract

Abstract: Osteosarcoma is a kind of common orthopedic malignancies with poor prognosis.With rapid development of new techniques in recent years,the result of osteosarcoma is getting better and better.However,there is still no thorough treatment for this disease.With the development of molecular biology,more and more attention is focusing on the role of various signaling pathways in osteosarcoma.One of the signaling pathways is TWEAK/Fn14.It may play an important role in the formation of osteosarcoma.Research progress of the potential relationship between TWEAK/Fn14 signaling pathway and osteosarcoma will be elaborated and discussed.

Key words: Osteosarcoma, Treatment, Molecular biology, Signaling pathway, TWEAK/Fn14

CLC Number:

R738.1

YU Tao,YU Guang-rong. A potential target for treatment of osteosarcoma:TWEAK/Fn14 signaling pathway[J]. 外科研究与新技术, 2013, 2(1): 62-65.

References

[1] 徐万鹏.骨科肿瘤学[M].2版.北京:人民军医出版社,2008:6-7.
[2] Ferrari S,Smeland S,Mercuri M,et al.Neoadjuvant chemotherapy with high-dose Ifosfamide,high-dose methotrexate,cisplatin,and doxorubicin for patients with localized osteosarcoma of the extremity:a joint study by the Italian and Scandinavian Sarcoma Groups[J].J Clin Oncol,2005,23(34):8845-8852.
[3] Wittig JC,Bickels J,Priebat D,et al.Osteosarcoma:a multidisciplinary approach to diagnosis and treatment[J].Am Fam Physician,2002,65(6):1123-1132.
[4] Kang Q,Sun MH,Cheng H,et al.Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery[J].Gene Ther,2004,11(17):1312-1320.
[5] Martelli L,Di MF,Botti P,et al.Accumulation,platinum-DNA adduct formation and cytotoxicity of cisplatin,oxaliplatin and satraplatin in sensitive and resistant human osteosarcoma cell lines,characterized by p53 wild-type status[J].Biochem Pharmacol,2007,74(1):20-27.
[6] Hoang BH.Wnt,osteosarcoma,and future therapy[J].J Am Acad Orthop Surg,2012,20(1):58-59.
[7] McQueen P,Ghaffar S,Guo Y,et al.The Wnt signaling pathway:implications for therapy in osteosarcoma[J].Expert Rev Anticancer Ther,2011,11(8):1223-1232.
[8] Modder UI,Oursler MJ,Khosla S,et al.Wnt10b activates the Wnt,notch,and NFkappaB pathways in U2OS osteosarcoma cells[J].J Cell Biochem,2011,112(5):1392-1402.
[9] Dieudonne FX,Marion A,Hay E,et al.High Wnt signaling represses the proapoptotic proteoglycan syndecan-2 in osteosarcoma cells[J].Cancer Res,2010,70(13):5399-5408.
[10] Rubin EM,Guo Y,Tu K,et al.Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma[J].Mol Cancer Ther,2010,9(3):731-741.
[11] Cai Y,Mohseny AB,Karperien M,et al.Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma[J].J Pathol,2010,220(1):24-33.
[12] Zhang P,Yang Y,Nolo R,et al.Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness[J].Oncogene,2010,29(20):2916-2926.
[13] Tanaka M,Setoguchi T,Hirotsu M,et al.Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation[J].Br J Cancer,2009,100(12):1957-1965.
[14] Engin F,Bertin T,Ma O,et al.Notch signaling contributes to the pathogenesis of human osteosarcomas[J].Hum Mol Genet,2009,18(8):1464-1470.
[15] Warzecha J,Dinges D,Kaszap B,et al.Effect of the Hedgehog-inhibitor cyclopamine on mice with osteosarcoma pulmonary metastases[J].Int J Mol Med,2012,29(3):423-427.
[16] Nagao H,Ijiri K,Hirotsu M,et al.Role of GLI2 in the growth of human osteosarcoma[J].J Pathol,2011,224(2):169-179.
[17] Zhang G,Li M,Zhu X,et al.Knockdown of akt sensitizes osteosarcoma cells to apoptosis induced by Cisplatin treatment[J].Int J Mol Sci,2011,12(5):2994-3005.
[18] Zhang B,Shi ZL,Liu B,et al.Enhanced anticancer effect of gemcitabine by genistein in osteosarcoma:the role of Akt and nuclear factor-kappaB[J].Anticancer Drugs,2010,21(3):288-296.
[19] Xie X,Yin J,Jia Q,et al.Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt[J].Oncol Rep,2011,26(3):687-693.
[20] Yu Y,Luk F,Yang JL,et al.Ras/Raf/MEK/ERK pathway is associated with lung metastasis of osteosarcoma in an orthotopic mouse model[J].Anticancer Res,2011,31(4):1147-1152.
[21] Tsubaki M,Yamazoe Y,Yanae M,et al.Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF,HGF,and TGF-beta as angiogenic factors in mouse osteosarcoma[J].Cytokine,2011,54(1):100-107.
[22] Geryk-Hall M,Yang Y,Hughes DP.Driven to death:inhibition of farnesylation increases Ras activity in osteosarcoma and promotes growth arrest and cell death[J].Mol Cancer Ther,2010,9(5):1111-1119.
[23] Tomonaga M,Hashimoto N,Tokunaga F,et al.Activation of nuclear factor-kappa B by linear ubiquitin chain assembly complex contributes to lung metastasis of osteosarcoma cells[J].Int J Oncol,2012,40(2):409-417.
[24] Nishimura A,Akeda K,Matsubara T,et al.Transfection of NF-kappaB decoy oligodeoxynucleotide suppresses pulmonary metastasis by murine osteosarcoma[J].Cancer Gene Ther,2011,18(4):250-259.
[25] Chicheportiche Y,Bourdon PR,Xu H,et al.TWEAK,a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis[J].J Biol Chem,1997,272(51):32401-32410.
[26] Hansson GK.Inflammation,atherosclerosis,and coronary artery disease[J].N Engl J Med,2005,352(16):1685-1695.
[27] Feng SL,Guo Y,Factor VM,et al.The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas[J].Am J Pathol,2000,156(4):1253-1261.
[28] Winkles JA,Tran NL,Brown SA,et al.Role of TWEAK and Fn14 in tumor biology[J].Front Biosci,2007,12:2761-2771.
[29] Schapira K,Burkly LC,Zheng TS,et al.Fn14-Fc fusion protein regulates atherosclerosis in ApoE-/-mice and inhibits macrophage lipid uptake in vitro[J].Arterioscler Thromb Vasc Biol,2009,29(12):2021-2027.
[30] Sugito T,Mineshiba F,Zheng C,et al.Transient TWEAK overexpression leads to a general salivary epithelial cell proliferation[J].Oral Dis,2009,15(1):76-81.
[31] Haile WB,Echeverry R,Wu J,et al.The interaction between tumor necrosis factor-like weak inducer of apoptosis and its receptor fibroblast growth factor-inducible 14 promotes the recruitment of neutrophils into the ischemic brain[J].J Cereb Blood Flow Metab,2010,30(6):1147-1156.
[32] Yanaba K,Yoshizaki A,Muroi E,et al.Elevated circulating TWEAK levels in systemic sclerosis:association with lower frequency of pulmonary fibrosis[J].J Rheumatol,2009,36(8):1657-1662.
[33] Ando T,Ichikawa J,Wako M,et al.TWEAK/Fn14 interaction regulates RANTES production,BMP-2-induced differentiation,and RANKL expression in mouse osteoblastic MC3T3-E1 cells[J].Arthritis Res Ther,2006,8(5):R146.
[34] Polek TC,Talpaz M,Darnay BG,et al.TWEAK mediates signal transduction and differentiation of RAW264.7 cells in the absence of Fn14/TweakR.Evidence for a second TWEAK receptor[J].J Biol Chem,2003,278(34):32317-3223.
[35] Lynch CN,Wang YC,Lund JK,et al.TWEAK induces angiogenesis and proliferation of endothelial cells[J].J Biol Chem,1999,274(13):8455-8459.
[36] Jakubowski A,Browning B,Lukashev M,et al.Dual role for TWEAK in angiogenic regulation[J].J Cell Sci,2002,115(2):267-274.
[37] Donohue PJ,Richards CM,Brown SA,et al.TWEAK is an endothelial cell growth and chemotactic factor that also potentiates FGF-2 and VEGF-A mitogenic activity[J].Arterioscler Thromb Vasc Biol,2003,23(4):594-600.
[38] Tran NL,McDonough WS,Donohue PJ,et al.The human Fn14 receptor gene is up-regulated in migrating glioma cells in vitro and overexpressed in advanced glial tumors[J].Am J Pathol,2003,162(4):1313-1321.
[39] Pradet-Balade B,Medema JP,Lopez-Fraga M,et al.An endogenous hybrid mRNA encodes TWE-PRIL,a functional cell surface TWEAK-APRIL fusion protein[J].EMBO J,2002,21(21):5711-5720.
[40] Kawakita T,Shiraki K,Yamanaka Y,et al.Functional expression of TWEAK in human hepatocellular carcinoma:possible implication in cell proliferation and tumor angiogenesis[J].Biochem Biophys Res Commun,2004,318(3):726-733.
[41] Ho DH,Vu H,Brown SA,et al.Soluble tumor necrosis factor-like weak inducer of apoptosis overexpression in HEK293 cells promotes tumor growth and angiogenesis in athymic nude mice[J].Cancer Res,2004,64(24):8968-8972.
[42] Michaelson JS,Cho S,Browning B,et al.Tweak induces mammary epithelial branching morphogenesis[J].Oncogene,2005,24(16):2613-2624.
[43] Kawakita T,Shiraki K,Yamanaka Y,et al.Functional expression of TWEAK in human colonic adenocarcinoma cells[J].Int J Oncol,2005,26(1):87-93.
[44] Jakubowski A,Ambrose C,Parr M,et al.TWEAK induces liver progenitor cell proliferation[J].J Clin Invest,2005,115(9):2330-2340.
[45] Nakayama M,Ishidoh K,Kayagaki N,et al.Multiple pathways of TWEAK-induced cell death[J].J Immunol,2002,168(2):734-743.
[46] Lin BR,Huang MT,Chen ST,et al.Prognostic Significance of TWEAK Expression in Colorectal Cancer and Effect of Its Inhibition on Invasion[J].Ann Surg Oncol,2011,19(3):385-394.
[47] Campbell S,Burkly LC,Gao HX,et al.Proinflammatory effects of TWEAK/Fn14 interactions in glomerular mesangial cells[J].J Immunol,2006,176(3):1889-1898.
[48] Zhou H,Marks JW,Hittelman WN,et al.Development and characterization of a potent immunoconjugate targeting the Fn14 receptor on solid tumor cells[J].Mol Cancer Ther,2011,10(7):1276-1288.

A potential target for treatment of osteosarcoma:TWEAK/Fn14 signaling pathway

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