FRAX模型评估中国老年2型糖尿病患者骨折风险的价值

doi:10.3969/j.issn.2095-378X.2021.01.003

Abstract

Abstract: Objective To assess the fracture risk of elderly patients with and without type 2 diabetes mellitus （T2DM） by FRAX model, and to ascertain the validity of this model in assessing the fracture risk of elderly patients with T2DM in the mainland of China. Methods A total of 267 T2DM and 359 non-diabetic （control） patients were randomly selected, completed a questionnaire survey, underwent bone mineral density measurement, and were assessed by FRAX model. Binary regression analysis was used to evaluate the risk factors for high-risk fracture predicted by FRAX model. Results The body mass index （BMI）, waist-hip ratio, and the proportions of smoking and drinking were all higher in the T2DM group than those in the control group （P<0.001）. The bone mineral content, T value, and Z value of femoral neck （FN） and lumbar vertebra （L） in the T2DM group were also high. The T2DM group showed lower risks of 10-year major osteoporotic fracture （MOF） and hip fracture （HF） by FRAX-BMI model than the control group ［（4.27±2.84）% vs. （5.14±2.92）%, P<0.001, and （1.42±1.54）% vs. （1.83±2.23）%, P<0.001］. The T2DM group also showed a lower risk of MOF by FRAX-BMD model than the control group ［（5.28±4.41）% vs. （6.30±5.10）%, P<0.001］. Regression analysis results showed that the T score of FN, smoking, family history of hip fracture, and glucocorticoid use were associated with high-risk HF. The T score of FN, smoking, family history of HF, and history of brittle fracture were associated with high-risk MOF. T2DM was not associated with high-risk fracture predicted by the FRAX model. Conclusion The FRAX model predicts a lower 10-year fracture risk in elderly Chinese patients with T2DM than in non-diabetic patients, indicating that the model is not well suited for the Chinese population.

Key words: Type 2 diabetes mellitus, Fracture risk, Bone mineral density, Fracture risk assessment tool

CLC Number:

R656

XIE Zhuangli, YANG Jun, XUAN Miao, JI Peifang, LI Ying. Value of FRAX model in assessing fracture risk of Chinese elderly adults with type 2 diabetes[J]. Surgical Research and New Technique, 2021, 10(1): 9-13.

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Value of FRAX model in assessing fracture risk of Chinese elderly adults with type 2 diabetes

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