Abstract: Objective To compare the impact of abdominal transverse small incision inguinal hernia repair and laparoscopic transabdominal preperitoneal repair （TAPP） on inflammation and pain of patients with inguinal hernia. Methods A retrospective analysis was conducted on the clinical data of 80 patients with inguinal hernia admitted to our hospital from January 2023 to December 2025. According to the surgical method, they were divided into an open group （n=40, undergoing abdominal transverse small incision hernia repair） and an abdominal group （n=40, undergoing TAPP）. The levels of inflammatory factors C-reactive protein （CRP）, interleukin 6 （IL-6）, tumor necrosis factor α （TNF-α）, pain intensity visual analog scale （VAS） score, and postoperative complications at different time points between the groups were compared. Results The increase in inflammatory indicators CRP, IL-6, and TNF-α in the abdominal group at 24 and 72 h after surgery was lower than that in the open group （P<0.05）. The VAS scores in the abdominal group at each time point were also lower than those in the open group （P<0.05）. There was no significant difference in the incidence of complications between the two groups （P>0.05）. Conclusion Compared with the abdominal transverse small incision surgery, TAPP can reduce systemic inflammatory response after trauma, alleviate early pain, and not increase the risk of additional complications, which is helpful for rapid recovery of patients and worthy of promotion in clinical practice.

Key words: Inguinal hernia, Abdominal transverse small incision inguinal herniorrhaphy, Laparoscopic transabdominal preperitoneal repair, Inflammatory factors, Pain level