Abstract: Objective To summarize the nursing key points of radioimmunotherapy of pancreatic cancer by observing the nursing care in 14 patients with advanced pancreatic cancer receiving injection of ¹³¹I-chTNT (iodine-131-lablbed tumor necrosis therapy chimeric antibody).Methods All pancreatic cancer patients (n=14) were treated with computed tomography(CT) guided ¹³¹I-chTNT intratumoral injection, and received comprehensive nursing including preoperative health education and postoperative complication nursing care.Results All patients were successfully treated with ¹³¹I-chTNT intratumoral injection with scientific, systematic, and meticulous nursing.The success rate was 100%.Specifically, 1 case had a complete response (CR) (7%), 4 cases achieved partial response (PR) (29%), 7 cases had stable conditions (50%), and 4 cases progressed (14%).The effective rate was 36%.Conclusions These promising Results demonstrate that sufficient doses of ¹³¹I-chTNT can be safely delivered to tumors to cause significant therapeutic effects on advanced pancreatic cancer.Perioperative psychological nursing, monitoring of vital signs, prevention and nursing of complications are a powerful guarantee for successful operation and prevention of complications.

Key words: ¹³¹I-chTNT, Pancreatic cancer, Radioimmunotherapy, Nursing